The Webb Lab’s work on WARS2 combines iPSC-derived neuronal models, a knock-in mouse model, and a patient registry to investigate the impact of WARS2 mutations on neurodevelopment and mitochondrial function. Excitatory neurons are generated from both patient and corrected iPSC lines to study metabolic dysregulation in human neurons. A mouse model with a WARS2 mutation helps examine broader physiological effects. The patient registry tracks clinical data and outcomes, further supporting the lab’s research. These combined approaches aim to uncover how WARS2 mutations affect neuronal function and contribute to neurodevelopmental disorders.
Elijah's Project for Hope
The Webb Lab works closely with this organization and is grateful for their generous support and funding.
The Texas-based non-profit organization Elijah’s Project for Hope has awarded Bryn Webb, MD, a two-year research grant to investigate a rare genetic disorder that results from mutations in the WARS2 gene.The Elijah’s Project for Hope organization was created in part to seek out researchers willing to study WARS2. Its initiator, Eric Williams, attended a symposium where Webb presented on MARS2, a related gene. The work she presented aligned with his vision for the first research project for Elijah’s Project for Hope.